Carolyn Bertozzi, Morten Meldal och Barry Sharpless (Nobelkommittén)

Trio får Nobelpriset för klickkemi: ”Handlar om att inte krångla till det”

Carolyn Bertozzi, Morten Meldal och Barry Sharpless tilldelas årets Nobelpris i kemi för ett ”funktionellt sätt att bygga molekyler”, meddelar Kungliga vetenskapsakademien.

Amerikanen Barry Sharpless och dansken Morten Meldal har lagt grunden för en funktionell form av kemi – klickkemi – där molekylära byggstenar snabbt och effektivt snäpper i varandra, skriver akademien i ett pressmeddelande. Carolyn Bertozzi, även hon från USA, anses i sin tur ha tagit klickkemin till en ny dimension och fört in den i levande organismer.

Inom läkemedelsforskningen har klickkemi ofta handlat om att på konstgjord väg återskapa naturliga molekyler som har läkande egenskaper, skriver TT. Men sådana molekylbyggen kan generellt vara tidskrävande och väldigt dyra att få fram.

– Årets kemipris handlar om att inte krångla till det så mycket och i stället utgå från det lätta och enkla. Även om man väljer en enkel väg kan man bygga avancerade och användbara molekyler, säger Johan Åqvist, ordförande i Nobelkommittén för kemi.

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Bakgrund

 
Carolyn R Bertozzi
Wikipedia (en)
Carolyn Ruth Bertozzi (born October 10, 1966) is a prolific American chemist and Nobel laureate known for her wide-ranging work spanning both chemistry and biology. She coined the term "bioorthogonal chemistry" for chemical reactions compatible with living systems. Her recent efforts include synthesis of chemical tools to study cell surface sugars called glycans and how they impact diseases such as cancer, inflammation, and viral infections like COVID-19. At Stanford University, she holds the Anne T. and Robert M. Bass Professorship in the School of Humanities and Sciences. Bertozzi is also an Investigator at the Howard Hughes Medical Institute (HHMI) and is the former Director of the Molecular Foundry, a nanoscience research center at Lawrence Berkeley National Laboratory. She received the MacArthur "genius" award at age 33. In 2010, she was the first woman to receive the prestigious Lemelson-MIT Prize faculty award. She is a member of the National Academy of Sciences (2005), the Institute of Medicine (2011), and the National Academy of Inventors (2013). In 2014, it was announced that Bertozzi would lead ACS Central Science, the American Chemical Society's first peer-reviewed open access journal, which offers all content free to the public. As an open lesbian in academia and science, Bertozzi has been a role model for students and colleagues.Bertozzi was awarded one third of the 2022 Nobel Prize in Chemistry, jointly with Morten P. Meldal and Karl Barry Sharpless, "for the development of click chemistry and bioorthogonal chemistry".
 
Morten Meldal
Wikipedia (en)
Morten P. Meldal (born 16 January 1954) is a Danish chemist. He is a professor of Chemistry at University of Copenhagen in Copenhagen, Denmark. He is best known for developing the CuAAC-click reaction, concurrent with but independent of Valery V. Fokin and K. Barry Sharpless.Meldal was awarded one third of the 2022 Nobel Prize in Chemistry, jointly with Carolyn R. Bertozzi and Karl Barry Sharpless, "for the development of click chemistry and bioorthogonal chemistry".
 
Barry Sharpless
Wikipedia (en)
Karl Barry Sharpless (born April 28, 1941) is an American chemist and a two-time Nobel laureate in Chemistry known for his work on stereoselective reactions and click chemistry. Sharpless was awarded half of the 2001 Nobel Prize in Chemistry "for his work on chirally catalysed oxidation reactions", and one third of the 2022 prize, jointly with Carolyn R. Bertozzi and Morten P. Meldal, "for the development of click chemistry and bioorthogonal chemistry".
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