Donald Trump / forskare på Regeneron arbetar med att framställa regn-cov2 (TT)

Läkare om medicineringen: ”Känns som att de öser på för att det är presidenten”

Flera av läkemedlen som Donald Trump behandlats med efter att ha testat positivt för covid-19 är inte medicinskt beprövade, rapporterar flera medier som har låtit läkare uttala sig i frågan.

– Det känns som att de öser på för att det är presidenten det handlar om, säger Anders Sönnerborg, professor i klinisk virologi och infektionssjukdomar, till DN.

Trump har behandlats med det testade och godkända remdesivir, magsyrehämmaren famotodin, som i provrör har visat sig kunna hindra coronaviruset, samt företaget Regenerons experimentella antikroppscocktail regn-cov2. Det senare är en kur som genomgår kliniska tester och ännu inte har godkänts av myndigheter.

Jeremy Faust, akutläkare vid Brigham and Women's Hospital i Boston, säger till Sky News att han inte skulle ge regn-cov2 till sina patienter eftersom både riskerna och den eventuella nyttan är oklara.

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Remdesivir
Wikipedia (en)
Remdesivir, sold under the brand name Veklury, is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences. It is administered via injection into a vein. Remdesivir is being tested as a treatment for COVID‑19, and has been authorized for emergency use in the US, India, Singapore, and approved for use in Japan, the European Union, and Australia for people with severe symptoms. It also received approval in the UK in May 2020; however, it was going to be rationed due to limited supply. It may shorten the time it takes to recover from the infection.The most common side effect in healthy volunteers is raised blood levels of liver enzymes (a sign of liver problems). The most common side effects in people with COVID‑19 is nausea (feeling sick).Side effects may include liver inflammation and an infusion-related reaction with nausea, low blood pressure, and sweating. It is a prodrug that is intended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase.Earlier studies found antiviral activity against several RNA viruses including SARS coronavirus and MERS coronavirus, but it is not approved for any indication. Remdesivir was originally developed to treat hepatitis C and was then tested against Ebola virus disease and Marburg virus disease, but was ineffective for all of these viral infections.
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Famotodin
Wikipedia (en)
Famotidine, sold under the brand name Pepcid among others, is a medication that decreases stomach acid production. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. It is taken by mouth or by injection into a vein. It begins working within an hour.Common side effects include headache, intestinal upset, and dizziness. Serious side effects may include pneumonia and seizures. Use in pregnancy appears safe but has not been well studied while use during breastfeeding is not recommended. It is a histamine H2 receptor antagonist.Famotidine was patented in 1979 and came into medical use in 1985. It is available as a generic medication. A month supply in the United Kingdom costs the NHS about £30 as of 2019. In the United States the wholesale cost of this amount is about $2. In 2017, it was the 115th most commonly prescribed medication in the United States, with more than six million prescriptions.
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Regn-cov2
Wikipedia (en)
REGN-COV2 is an experimental drug developed by the American biotechnology company Regeneron Pharmaceuticals. It is an artificial "antibody cocktail" designed to produce resistance to the SARS-CoV-2 coronavirus responsible for the COVID-19 pandemic. It consists of a mixture of two monoclonal antibodies, REGN10933 and REGN10987. The combination of several antibodies is intended to prevent mutational escape.As of September 2020, REGN-COV2 is being evaluated as part of the RECOVERY Trial.Regeneron has a deal in place with Hoffmann-La Roche to manufacture and market REGN-COV2 outside the United States.Regeneron Pharmaceuticals provided "a single 8 gram dose of REGN-COV2" in response to a "compassionate use" request from the president’s physicians after President Donald Trump tested positive for COVID-19.

Mer om Trumps positiva coronatest

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