Isabelle Nordström

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Coronaviruset

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An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into immune cells, which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus) or by a cancer cell. These protein molecules stimulate an adaptive immune response that teaches the body to identify and destroy the corresponding pathogen or cancer cells. The mRNA is delivered by a co-formulation of the RNA encapsulated in lipid nanoparticles that protect the RNA strands and help their absorption into the cells.

Reactogenicity, the tendency of a vaccine to produce adverse reactions, is similar to that of conventional non-RNA vaccines. People susceptible to an autoimmune response may have an adverse reaction to messenger RNA vaccines. The advantages of mRNA vaccines over traditional vaccines are ease of design, speed and lower cost of production, the induction of both cellular and humoral immunity, and lack of interaction with the genomic DNA. While some messenger RNA vaccines, such as the Pfizer–BioNTech COVID-19 vaccine, have the disadvantage of requiring ultracold storage before distribution, other mRNA vaccines, such as the Moderna, CureVac, and Walvax COVID-19 vaccines, do not have such requirements.In RNA therapeutics, messenger RNA vaccines have attracted considerable interest as COVID-19 vaccines. In December 2020, Pfizer–BioNTech and Moderna obtained authorization for their mRNA-based COVID-19 vaccines. On 2 December, the UK Medicines and Healthcare products Regulatory Agency (MHRA) became the first medicines regulator to approve an mRNA vaccine, authorizing the Pfizer–BioNTech vaccine for widespread use. On 11 December, the US Food and Drug Administration (FDA) issued an emergency use authorization for the Pfizer–BioNTech vaccine and a week later similarly authorized the Moderna vaccine.

MRNA vaccine

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Helena Sällström

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Joel Malmén

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Omni Ekonomi

Jon Velander

Patrik Jäverbo

Praktikertjänst

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Chinese New Year is the festival that celebrates the beginning of a new year on the traditional lunisolar Chinese calendar. In Chinese, the festival is commonly referred to as the Spring Festival (traditional Chinese: 春節; simplified Chinese: 春节; pinyin: Chūnjié) as the spring season in the lunisolar calendar traditionally starts with lichun, the first of the twenty-four solar terms which the festival celebrates around the time of the Chinese New Year. Marking the end of winter and the beginning of the spring season, observances traditionally take place from New Year’s Eve, the evening preceding the first day of the year to the Lantern Festival, held on the 15th day of the year. The first day of Chinese New Year begins on the new moon that appears between 21 January and 20 February.Chinese New Year is one of the most important holidays in Chinese culture, and has strongly influenced Lunar New Year celebrations of its 56 ethnic groups, such as the Losar of Tibet (Tibetan: ལོ་གསར་), and of China's neighbours, including the Korean New Year (Korean: 설날; RR: Seollal), and the Tết of Vietnam, as well as in Okinawa. It is also celebrated worldwide in regions and countries that houses significant Overseas Chinese or Sinophone populations, especially in Southeast Asia. These include Brunei, Cambodia, Indonesia, Malaysia, Myanmar, the Philippines, Singapore, Thailand, and Vietnam. It is also prominent beyond Asia, especially in Australia, Canada, Mauritius, New Zealand, Peru, South Africa, the United Kingdom, and the United States, as well as various European countries.The Chinese New Year is associated with several myths and customs. The festival was traditionally a time to honor deities as well as ancestors. Within China, regional customs and traditions concerning the celebration of the New Year vary widely, and the evening preceding the New Year's Day is frequently regarded as an occasion for Chinese families to gather for the annual reunion dinner. It is also a tradition for every family to thoroughly clean their house, in order to sweep away any ill fortune and to make way for incoming good luck. Another custom is the decoration of windows and doors with red paper-cuts and couplets. Popular themes among these paper-cuts and couplets include good fortune or happiness, wealth, and longevity. Other activities include lighting firecrackers and giving money in red envelopes.



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