Flera fall av brasilianska varianten i Storbritannien

Lineage P.1, also known as 20J/501Y.V3, Variant of Concern 202101/02 (VOC-202101/02) or colloquially known as the Brazil(ian) variant,, is one of the variants of SARS-CoV-2, the virus that causes COVID-19. This variant of SARS-CoV-2 has been named P.1 lineage and has 17 unique amino acid changes, 10 of which in its spike protein, including these 3 designated to be of particular concern: N501Y, E484K and K417T. This variant of SARS-CoV-2 was first detected by the National Institute of Infectious Diseases (NIID), Japan, on 6 January 2021 in four people who had arrived in Tokyo having visited Amazonas, Brazil four days earlier. It was subsequently declared to be in circulation in Brazil.It has caused widespread infection in the city of Manaus, despite the fact that the city had already experienced widespread infection in May with a study indicating high seroprevalence of antibodies for SARS-CoV-2. P.1 has also been called 'B.1.1.28.1', although strictly only three sublevels are permitted in the PANGO Lineage system of nomenclature, hence the designation 'P.1'.P.1 comprises the two distinct subvariants 28-AM-1 and 28-AM-2, which both carry the K417T, E484K, N501Y mutations, and both developed independently of each other within the same Brazilian Amazonas region.P.1 is notably different from the other Brazilian P.2 lineage (also called 'B.1.1.28.2' or 'VUI-202101/01', which originated from Rio de Janeiro). In particular, P.2 only carries the E484K mutation and has neither of the other two concerning N501Y and K417T mutations.