Professor: ”Är ett exempel på förstklassig forskning”
Nobelpristagarna William G Kaelins Jr, Sir Peter J Ratcliffes och Gregg L Semenzas gärning är ett exempel på ”förstklassig forskning” av väldigt hög kvalitet. Det säger Lena Claesson-Welsh, professor i medicinsk biokemi vid Uppsala universitet.
– Tar man tid att läsa litteraturen från dem imponeras man, säger hon i Ekots sändning.
Hon imponeras särskilt av att alla tre varit kliniskt aktiva som läkare och haft forskningen vid sidan av. Hon hoppas att priset nu kan få fler att upptäcka pristagarnas område om hur celler påverkas av syre.
Mer om pristagarna
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William Kaelin Jr.
Wikipedia (en)
William "Bill" G. Kaelin Jr. (born 1957 in New York City) is a professor of medicine at Harvard University. Kaelin is a 2019 Nobel laureate in Physiology or Medicine and a 2016 recipient of the Lasker Award for Basic Medical Research. He also has won the 2016 ASCO Science of Oncology Award, and 2016 AACR Princess Takamatsu Award. His laboratory studies tumor suppressor proteins.
He became Assistant Director of Basic Science at the Dana-Farber/Harvard Cancer Center in 2008. His research at Dana-Farber has focused on understanding the role of mutations in tumor suppressor genes in cancer development. His major work has been on the retinoblastoma, von Hippel-Lindau, and p53 tumor suppressor genes.
His work has been funded by the National Institutes of Health, American Cancer Society, Doris Duke Charitable Foundation and others.Kaelin earned his bachelor's in math and chemistry at Duke University, and remained for his MD, graduating in 1982. He did his residency in internal medicine at Johns Hopkins and oncology fellowship at Dana-Farber Cancer Institute. After deciding as an undergraduate that research was not a strength of his, at DFCI he did research in the lab of David Livingston, where he found success in the study of retinoblastoma. In 1992, he set up his own lab at DFCI down the hall from Livingston's where he researched hereditary forms of cancer such as von Hippel-Lindau. He became a professor at Harvard Medical School in 2002.He is a member of the board of directors at Eli Lilly and the Stand Up to Cancer scientific advisory committee.He was married to breast cancer surgeon Dr. Carolyn Kaelin (Scerbo) from 1988 until her death from cancer in 2015. They have two children.
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Gregg L. Semenza
Wikipedia (en)
Gregg L. Semenza is the C. Michael Armstrong professor of pediatrics, radiation oncology, biological chemistry, medicine, and oncology at the Johns Hopkins University School of Medicine. He serves as the director of the vascular program at the Institute for Cell Engineering. He is a 2016 recipient of the Lasker Award for Basic Medical Research. He is known for his discovery of HIF-1, which allows cancer cells to adapt to oxygen-poor environments. He received the 2019 Nobel Prize in Physiology or Medicine for "discoveries of how cells sense and adapt to oxygen availability". He studied beta thalassemia while doing his PhD at the University of Pennsylvania.
bakgrund
Peter J. Ratcliffe
Wikipedia (en)
Sir Peter John Ratcliffe FRS (born 14 May 1954) is a British doctor and cell and molecular biologist best known for his work on cellular reactions to hypoxia, for which he shared the Nobel Prize in Physiology or Medicine in 2019. He is a practicing clinician at the John Radcliffe Hospital, Oxford and has been Nuffield Professor of Clinical Medicine and head of the Nuffield Department of Clinical Medicine at the University of Oxford since 2004. Since 2016 he has been the director of the Target Discovery Institute, University of Oxford, and Clinical Research Director, at the Francis Crick Institute.
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